结缔组织病是临床常见病,由于多伴有一些神经精神症状,常给诊断带来一定困难,本文仅就结缔组织病的神经精神表现介绍于下: 1.系统性红斑狼疮:女性多见,约占80％;年龄15～40岁;症状有颊部、鼻根部蝶形红斑、发热、关节痛、血沉快、LE细胞阳性、抗核抗体阳性,亦可有肾炎、心内膜炎、胸膜炎及间质性肺炎。神经系统症状发生率平均为15～37％,其中中枢神经损害占25～50％,周围神经损害占10～16％。癫癎是最常见的并发症,约占17～50％,其机制多数认为是脑皮质血管闭塞所致。疾病晚期出现的局限 Connective tissue disease is a common clinical disease, often accompanied by some neuropsychiatric symptoms, often bring some difficulties to the diagnosis, this article only on the neuropsychiatric manifestations of connective tissue disease introduced in the following: 1. SLE: more common in women, About 80%; aged 15 to 40 years old; symptoms are buccal, nasal papillary erythema, fever, joint pain, ESR, LE cells positive anti-nuclear antibody-positive, may also have nephritis, endocarditis, pleurisy And interstitial pneumonia. The average incidence of neurological symptoms 15 to 37%, of which 25 to 50% of central nervous system damage, peripheral nerve damage accounted for 10 to 16%. Epilepsy is the most common complication, accounting for about 17 to 50%, the majority of which is thought to be caused by cerebral cortex occlusion. Late limitations of the disease