前列腺特异性抗原(prostatespecificantigen,PSA)自被发现以来,受到临床上高度重视,经深入研究,目前已被公认为诊断前列腺癌(prostaticcan-cer,PCa)极具临床价值的指标。但PSA仅对前列腺组织特异而非PCa特有,作为早期诊断PCa的指标还缺乏足够的敏感性和特异性。特别是血清中PSA Prostate-specific antigen (PSA) has been clinically valued since it was discovered. It has been widely recognized as a clinically valuable indicator for the diagnosis of prostaticcan-cer (PCa). However, PSA is specific for prostate tissue rather than PCa, and lacks sufficient sensitivity and specificity for early diagnosis of PCa. Especially in serum PSA