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目的: 探讨保妇康栓治疗宫颈柱状上皮异位的疗效及对子宫颈组织细胞间黏附分子1(ICMI-1)、转化生长因子β1(TGF-β1)mRNA表达以及炎性细胞因子的影响.方法: 宫颈柱状上皮异位患者102例随机分为观察组和对照组,每组51例.观察组给予保妇康栓治疗,对照组给予冷冻治疗.均连续治疗7 d.观察两组临床疗效和不良反应情况,比较两组患者治疗前后子宫颈组织ICMI-1 mRNA和TGF-β1 mRNA表达及血清炎性细胞因子水平变化.结果: 观察组总有效率为94.12%,明显优于对照组(P＜0.05).两组治疗后ICMI-1 mRNA和TGF-β1 mRNA均较治疗前明显降低(P＜0.05),且观察组明显低于对照组(P＜0.05).对照组治疗前后白介素-6(IL-6)和白介素-1(IL-1)无明显变化(P＞0.05);观察组治疗后IL-6和IL-1较治疗前明显降低(P＜0.05),且低于对照组(P＜0.05).两组治疗前后月经期和月经周期无明显变化,未见不良反应发生.结论: 保妇康能有效治疗宫颈柱状上皮异位,降低宫颈柱状上皮异位患者子宫组织ICMI-1mRNA、TGF-β1m RNA表达以及血清炎性细胞因子水平.“,”Objective: To investigate the efficacy of Baofukang suppositories on cervical columnar epithelial ectopic and the influence on the expression of uterine tissue intercellular adhesion molecule 1 (ICMI-1), transforming growth factor b1 (TGF-b1) mRNA and inflammatory cytokines in cervical tissues.Methods: Totally 102 patients with cervical columnar epithelial ectopic were randomly divided into the observation group and the control group with 51 ones in each.The observation group received Baofukang suppositories, and the control group was treated with cryosurgery.The clinical efficacy was compared between the groups, and before and after the treatment, the levels of ICMI-1 mRNA, TGF-b1 mRNA and inflammatory cytokines were also recorded and compared.Results: The clinical curative effect of the observation group was 94.12%,which was better than that of the control group (P＜0.05).After the treatment, the levels of ICMI-1 mRNA and TGF-b1 mRNA decreased when compared with those before the treatment (P 0.05), while those in the observation group decreased after the treatment (P <0.05), which were significantly lower than those in the control group (P＜0.05).There were no significant changes in menstrual period and menstrual cycle in the two groups before and after the treatment, and no adverse reactions occurred during the treatment.Conclusion: Baofukang suppositories are effective in the treatment of columnar epithelial ectopic, which can reduce the levels of ICMI-1 mRNA, TGF-b1 mRNA and serum inflammatory cytokine in the patients.