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Gold等人从人的结肠腺癌分离出一种抗原性物质,它与胎儿肠组织分离者有相同的免疫性,故被称为癌胚抗原(Carcino-Embryonic Antigen CEA)。十多年来已经对CEA进行了大量的研究,特别是希望它有助于肠癌的早期诊断,但是随后证明它的特异性不高,非消化道癌肿以及非癌性病变和正常组织也有CEA或有免疫学上不能与CEA相区别的抗原性物质。近来普遍认为单独测定CEA水平不能预示大肠癌患者术后的转移及复发,为了寻找更有效的生化指标,Cooper等人把注意力转向测定血清中的α球白球。大肠癌患者血清α球蛋白常出现条乱。Cooper等指出大肠癌患者血清某些蛋白质含量有变化,如触球蛋白
Gold et al. isolated an antigenic substance from human colon adenocarcinoma, which has the same immunity as those isolated from fetal intestine tissue and is called Carcino-Embryonic Antigen CEA. Over the past decade, CEA has conducted a lot of research, especially in the hope that it will contribute to the early diagnosis of colorectal cancer, but then it proves that its specificity is not high, non-digestive cancer and non-cancerous lesions and normal tissues also have CEA may have antigenic substances that are immunologically indistinguishable from CEA. Recently, it is generally believed that the separate determination of CEA levels cannot predict the metastasis and recurrence of colorectal cancer patients. To find more effective biochemical markers, Cooper et al. turned their attention to the determination of serum α-globulin. Patients with colorectal cancer serum alpha globulin often appear disordered. Cooper et al. pointed out that some patients with colorectal cancer have some changes in serum protein content, such as contact globulin.