Many fish stocks in the world are depleted as a result of overexploitation, which reduces stock productivity and results in loss of potential yields. In this study we analyzed the catch trends and approximate thresholds of sustainable fishing for fished stocks to estimate the potential loss of catch and revenue of global fisheries as a result of overexploitation during the period of 1950–2010 in 14 FAO fishing areas. About 35% of stocks in the global marine ocean have or had suffered from overexploitation at present. The global catch losses amounted to 332.8 million tonnes over 1950–2010, resulting in a direct economic loss of US$298.9 billion(constant 2005 US$).Unsustainable fishing caused substantial potential losses worldwide, especially in the northern hemisphere.Estimated potential losses due to overfishing for different groups of resources showed that the low-value but abundant small-medium pelagics made the largest contribution to the global catch loss, with a weight of 265.0 million tonnes. The geographic expansion of overfishing not only showed serial depletion of world’s fishery resources, but also reflected how recent trends towards sustainability can stabilize or reverse catch losses.Reduction of global fishing capacity and changes in fishery management systems are necessary if the long-term sustainability of marine fisheries in the world is to be achieved. Many fish stocks in the world are depleted as a result of overexploitation, which reduces stock productivity and results in loss of potential yields. In this study we analyzed the catch trends and approximate thresholds of sustainable fishing for fished stocks to estimate the potential loss of catch and revenue of global fisheries as a result of overexploitation during the period of 1950-2010 in 14 FAO fishing areas. About 35% of stocks in the global marine ocean have or had suffered from overexploitation at present. tonnes over 1950-2010, resulting in a direct economic loss of US $ 298.9 billion (constant 2005 US $). Unsustainable fishing led substantial potential losses worldwide, especially in the northern hemisphere. Estimated potential losses due to overfishing for different groups of resources showed that the low-value but abundant small-medium pelagics made the largest contribution to the global catch loss, with a weight of 265. 0 million tonnes. The geographic expansion of overfishing not only showed serial depletion of world’s fishery resources, but also reflected how recent trends towards sustainability can stabilize or reverse catch losses. Reduction of global fishing capacity and changes in fishery management systems are necessary if the long -term sustainability of marine fisheries in the world is to be achieved.