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本文对煤焦沥青诱发大鼠肺癌过程中的病理形态学所见作了报道。整个过程可以分为三个阶段:1.异物反应阶段;2.异常增生和鳞状化生阶段;3.癌肿发生发展阶段。文中对每一个阶段的病理组织学改变做了详细描述。煤焦沥青诱发的大鼠肺癌的特征如下:1.癌肿全都发生在肺的周边部位;2.绝大多数癌肿的组织类型都是高分化鳞状细胞癌;3.多发性,数个至数十个大小不等的肿块布满全肺;4.癌变各个不同阶段的改变可在同一肺脏中出现;5.转移癌较少见。
This article reports the pathological morphology of coal tar pitch-induced lung cancer in rats. The whole process can be divided into three stages: 1. Foreign reaction stage; 2. Abnormal hyperplasia and squamous metaplasia stage; 3. The stage of development of cancer. The article made a detailed description of the histopathological changes in each stage. Coal tar pitch-induced lung cancer in rats are characterized as follows: 1. All cancers occur in the periphery of the lungs; 2. The vast majority of cancerous tissue types are highly differentiated squamous cell carcinomas; 3. Multiple, multiple To dozens of lumps of varying sizes covered the whole lung; 4.Changes in various stages of canceration can occur in the same lung; 5. Metastatic cancers are rare.