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目的探讨大剂量甲基强的松龙治疗急性脊髓损伤的作用机理。方法４０只家兔分成３组，用改良Ａｌｅｎ法造成不完全性脊髓损伤，进行运动功能、脊髓诱发电位、血液流变学、脊髓丙二醛和病理对比观察。结果大剂量甲基强的松龙治疗组较损伤组运动功能的恢复显著提高，脊髓诱发电位波形分化较清晰，血液流变学明显改善，脊髓丙二醛含量下降，病理损害减轻。结论早期应用大剂量甲基强的松龙治疗脊髓损伤，可以改善脊髓组织的血液供应，减轻脊髓的继发性损伤，促进脊髓功能恢复。
Objective To investigate the mechanism of high dose methylprednisolone treatment of acute spinal cord injury. Methods Forty rabbits were divided into three groups, and incomplete spinal cord injury was induced by modified Alen method. Motor function, spinal cord evoked potentials, hemorrheology, and malondialdehyde in spinal cord were observed. Results The recovery of motor function in the high-dose methylprednisolone group was significantly higher than that in the injury group. The evoked potential waveform of spinal cord was well differentiated, the blood rheology was significantly improved, the content of malondialdehyde in the spinal cord was decreased and the pathological damage was alleviated. Conclusion Early application of high-dose methylprednisolone treatment of spinal cord injury can improve blood supply to the spinal cord tissue, reduce spinal cord secondary injury and promote spinal cord function recovery.