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目的：探讨谷胱甘肽过氧化物酶与牙周组织病的关系。方法：选择了１２例慢性龈炎，１３例单纯性牙周炎，９例健康对照，采用ＤＴＮＢ显色法测定酶的活性，对其病变龈组织做ＧＳＨ－ＰＸ测定，并分析了临床指标与实验室指标的相关关系。结果：１．龈炎组，ＧＳＨ－ＰＸ含量为２９３．７４±１２１．７０，牙周炎组为２４２．９７±１１０．５９，对照组７８１．２５±１１３．３９，龈炎组、牙周炎组的ＧＳＨ－ＰＸ活性显著低于对照组（Ｐ＜０．０１），龈炎组与牙周炎组ＧＳＨ－ＰＸ活性无显著差异（Ｐ＞０．０５）。２．龈炎组牙龈指数与ＧＳＨ－ＰＸ活性成负相关（ｒ＝－０．７２２５，Ｐ＜０．００５），牙周炎组牙周袋深度，附着丧失量与ＧＳＨ－ＰＸ活性成负相关（ｒ＝－０．７６５３，ｒ＝－０．８５７８，Ｐ＜０．００２５）。结论：牙周病变组织ＧＳＨ－ＰＸ活性降低可能有两方面的原因，其一是牙周病是细菌引起的非特异性炎症，由于细菌的存在，局部自由基生成增多对ＧＳＨ－ＰＸ消耗增大；其二是由于全身因素的影响局部ＧＨＳ－ＰＸ合成减少。
Objective: To investigate the relationship between glutathione peroxidase and periodontal disease. Methods: Twelve chronic gingivitis, 13 simple periodontitis and 9 healthy controls were selected. The enzyme activity was measured by DTNB colorimetric assay. GSH-PX was measured in the gingival tissues of the diseased and the clinical indexes Laboratory indicators related to the relationship. Results: 1. Gingivitis group, GSH-PX content was 293.74 ± 121.70, periodontitis group was 242.97 ± 110.59, control group 781.25 ± 113.39, gingivitis group, periodontitis group GSH -PX activity was significantly lower than the control group (P <0.01), gingivitis group and periodontitis group GSH-PX activity was no significant difference (P> 0.05). 2. The gingival index in gingivitis group was negatively correlated with GSH-PX activity (r = -0.7225, P <0.005). There was a negative correlation between the periodontal pocket depth and attachment loss and the activity of GSH-PX = -0.7653, r = -0.8578, P <0.0025). CONCLUSIONS: There are two possible reasons for the decrease of GSH-PX activity in periodontal tissues. One is that periodontal disease is a non-specific inflammation caused by bacteria. Due to the presence of bacteria, the generation of local free radicals increases the consumption of GSH-PX. The second is the decrease of local GHS-PX synthesis due to systemic factors.