目的分析不同程度的颅内动脉狭窄患者的既往史和血清亲环素A和网膜素水平的差异,并探讨颅内动脉狭窄的危险因素和亲环素A、网膜素与颅内动脉狭窄程度的关系。方法收集89例脑梗死患者临床资料,将患者分为颅内动脉多发狭窄组(n=29)、颅内动脉单发狭窄组(n=24)和对照组(n=36),应用ELISA方法测定血清亲环素A和网膜素水平。比较3组间既往史、血清亲环素A和网膜素水平的差异。结果在颅内动脉多发狭窄组、单发狭窄组、对照组既往史的比较中糖尿病史和既往脑卒中史具有显著差异(50.0%vs 29.2%vs 13.9%,P<0.017;58.6%vs 29.2%vs 27.8%,P<0.017),颅内动脉多发狭窄组的患者合并糖尿病史、既往脑卒中史的概率比另2组的概率显著增高;3组中血清亲环素A水平有显著差异[(11.040±3.166)ng/ml vs(7.984±4.550)ng/ml vs(2.433±2.433)ng/ml,P<0.05],颅内动脉多发狭窄组较颅内动脉单发狭窄组患者的血清亲环素A水平升高,且二者与对照组比较均有升高(P<0.05);与对照组相比较,颅内动脉多发狭窄组和颅内动脉单发狭窄组血清网膜素-1水平均有降低[(0.088±0.046)ng/ml vs(0.290±0.245)ng/ml,P<0.05;(0.242±0.182)ng/ml vs(0.290±0.245)ng/ml,P<0.05],但二者之间血清网膜素水平无显著差异(P<0.05)。结论患有糖尿病史或既往脑卒中史的患者更容易合并颅内动脉狭窄,糖尿病、既往脑卒中史可能是颅内动脉狭窄的危险因素;颅内动脉多发狭窄组血清亲环素A水平明显升高、网膜素水平明显降低,提示亲环素A可能参与颅内动脉狭窄的形成;血清网膜素水平与颅内动脉硬化狭窄有关,但与狭窄程度无关,提示颅内动脉狭窄患者可能存在内皮功能的受损。 Objective To analyze the past history of patients with intracranial arterial stenosis and the differences of serum levels of cyclophilin A and retinal pigment between different degrees of intracranial arterial stenosis and to explore the risk factors of intracranial arterial stenosis and the relationship between cyclophilin A, retinal and intracranial arterial stenosis Relationship. Methods The clinical data of 89 patients with cerebral infarction were collected and divided into multiple stenosis group (n = 29), single stenosis group (n = 24) and control group (n = 36) Serum cyclophilin A and retinal levels were measured. The differences of serum cyclophilin A and retinal levels between the 3 groups were compared. Results There was a significant difference in the history of diabetes mellitus and prior stroke among the prior arteries in the multiple intracranial stenosis group, the single stenosis group, and the control group (50.0% vs 29.2% vs. 13.9%, P <0.017; 58.6% vs 29.2% vs 27.8%, P <0.017). Patients with intracranial arterial multiple stenosis had a history of diabetes mellitus, the probability of previous stroke was significantly higher than that of the other two groups, and the level of serum cyclophilin A was significantly different among the three groups [( 11.040 ± 3.166 ng / ml vs 7.994 ± 4.550 ng / ml vs 2.433 ± 2.433 ng / ml respectively, P <0.05]. Compared with the patients with stenosed intracranial artery stenosis group, (P <0.05). Compared with the control group, the level of serum retinin-1 in patients with multiple stenosis of intracranial arteries and single stenosis of intracranial arteries was significantly higher than that of controls (0.088 ± 0.046) ng / ml vs (0.290 ± 0.245) ng / ml, P <0.05; 0.242 ± 0.182 ng / ml vs 0.290 ± 0.245 ng / ml, P <0.05] There was no significant difference in serum retinin between the two groups (P <0.05). Conclusions Patients with a history of diabetes mellitus or previous stroke are more likely to have intracranial arterial stenosis and diabetes mellitus. Previous stroke history may be a risk factor for intracranial arterial stenosis. Serum cyclophilin A levels were significantly increased in patients with multiple intracranial stenoses High, the level of retinal decreased significantly, suggesting that cyclophilin A may be involved in the formation of intracranial arterial stenosis; serum retinin levels and intracranial arteriosclerosis stenosis, but has nothing to do with the degree of stenosis, suggesting that patients with intracranial artery stenosis may exist Endothelial dysfunction.