论文部分内容阅读
本文就胶原病在消化系统的主要病变及其病理和处置讨论如下。硬皮病(PSS) PSS消化系统病变的主要特征是消化道运动异常。PSS主要是小血管闭塞性病变和结缔组织增生,其胶原增生、沉着主要在浆膜和肌层、粘膜下层。由于肌层萎缩,蠕动减弱,进一步使肠管吸收不良。本病90%以上出现不同程度的消化道运动障碍。PSS最易引起食道运动异常(96%),常出现钙沉着-雷诺氏-食道受累-硬指-毛细血管扩张(CRST)综合征。其次是小肠(40～60%)及大肠和胃。由于肌层胶原沉着、萎缩而致运动机能低下。食道蠕动减弱而呈纺锤型。食道下段括约肌(LES)弛缓,内容物停滞,胃内存物返流。因此,返流性食道炎发病率高,出现顽固性返酸。食道炎后遗症引起的瘢痕狭窄可导
This article on collagen disease in the digestive system of the main lesions and pathology and disposal are discussed below. Scleroderma (PSS) The main feature of PSS digestive system lesions is gastrointestinal motility disorders. PSS is mainly small vessel occlusive disease and connective tissue hyperplasia, its collagen proliferation, mainly in the serosa and myometrium, submucosa. Muscle atrophy, weakened peristalsis, to further make poor intestinal absorption. More than 90% of the disease with varying degrees of gastrointestinal disorders. PSS most likely causes esophageal motility abnormalities (96%), often with calyx - Raynaud’s - esophageal involvement - dystonia - telangiectasia (CRST) syndrome. Followed by the small intestine (40 ~ 60%) and the large intestine and stomach. Myofascial collagen due to atrophy and atrophy caused by motor dysfunction. Esophageal motility weakened spindle type. Lower esophageal sphincter (LES) flaccid, the contents of stagnation, reflux of the contents of the stomach. Therefore, the incidence of reflux esophagitis, refractory acid reflux. Squeamitis caused by esophageal sequelae can lead to stenosis