作者采用双盲法比较口服与静脉氟脲嘧啶(5-Fu)治疗晚期直结肠癌的差别。将 100例结直肠癌有转移的病人,将其分成两组,47例口服用药,20毫克/公斤/日,5天;53例静脉用药,13.5毫克/公斤/日,5天。均间隔5周再重复。比较其用药后的毒性反应,血中药物浓度及疗效。结果:一、毒性反应:胃肠道及粘膜皮肤反应在口服用药组虽较静脉组多些, The authors used a double-blind approach to compare the difference between oral and intravenous 5-fluorouracil (5-Fu) in the treatment of advanced colorectal cancer. In 100 patients with colorectal cancer metastases, they were divided into two groups. 47 patients were given oral medication, 20 mg/kg/day, for 5 days; 53 patients were intravenously administered, 13.5 mg/kg/day, for 5 days. Repeat at intervals of 5 weeks. Compare the toxicity of the drug after its use, blood drug concentration and efficacy. Results: 1. Toxic reactions: Gastrointestinal tract and mucosal skin reactions were more in the oral medication group than in the intravenous group.