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应用血源乙肝疫苗和基因工程乙肝疫苗，对婴幼儿和小学生按0、1、6免疫程序进行联合免疫的效果观察。结果第1、2针用血源苗，第3外用基因苗免疫的阳转率（82．9％）明显低于3针均用血源苗的阳转率；第1、2针用血源苗，第3针用基因苗与3针均用基因苗免疫的阳转率均达100％；用血源苗基础免疫，5年后用基因苗加强免疫的阳转率（98．2％）与用血源苗加强免疫的阳转率（100％）差异无显著意义，但加强免疫后的GMT值，基因苗（515．2）明显高于血源苗（31．6）。表明基因苗同样具有良好的免疫效果。
Application of Hepatitis B vaccine and genetically engineered hepatitis B vaccine, infants and pupils by 0,1,6 immunization program for combined immunization results. Results The positive rate of the first and second needle-use vaccine (82.9%) was obviously lower than that of the third needle-use vaccine The positive rate of immunization with gene vaccine was up to 100% for the seedling, the third needle and the three needles, respectively. The positive rate of immunization with the seedling vaccine was 98.2% There was no significant difference in the positive rate (100%) between the two groups. However, the GMT value after immunization was significantly higher than that of the blood-borne seedlings (515.2). That genetic vaccine also has a good immune effect.