长链非编码RNA(long noncoding RNA,lncRNA)是一类长度超过200个核苷酸的非编码RNA分子,无蛋白质编码功能,以RNA形式在表观遗传学、转录及转录后等多种水平调控基因表达,在病理生理过程中起着重要的调节作用。近期研究证据显示,原发性肝癌等肝脏疾病中有多种lncRNA表达水平发生了变化,并在肝癌发生、发展及预后中起着重要的调控作用,本文主要就lncRNA在原发性肝癌等肝脏疾病中的机制研究作一综述。 Long-chain non-coding RNA (lncRNA) is a class of non-coding RNA molecules longer than 200 nucleotides in length and has no protein coding function. The long noncoding RNA (lncRNA) is expressed in RNA form at epigenetic, transcription and post- Regulation of gene expression plays an important regulatory role in the pathophysiology. Recent evidence shows that a variety of liver diseases such as primary liver cancer lncRNA expression levels have changed, and plays an important regulatory role in the occurrence, development and prognosis of liver cancer, lncRNA mainly in liver and other primary liver cancer A review of the mechanism of disease.