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Baldwin 等1970年将狼疮肾炎按组织学分为局灶增殖、弥漫增殖和膜性等3型,随后又有作者增加了微小系膜病变(minimal mesangial lesion)型。虽然多数学者认为微小系膜性狼疮肾炎多呈良性病程,弥漫性狼疮肾炎多导致肾衰,但有关局灶性狼疮肾炎的预后仍存在不同看法。本文严格遵照世界卫生组织(WHO)的分类标准,从200例已作肾活检的系统性红斑狼疮患者中,选15例(7%)符合局灶性节段性狼疮肾炎诊断标准的患者,进行2～20(平均6.3)年的追踪观察,然后将其组织学变化联系临床过程(蛋白尿、高血压及肾功能的变化)进行综合分析。此15例的19次肾活检标本及1次尸体肾标本都经光学显微镜检查,其中17次肾活检标本还进行了电子显微镜检查,7次肾活检标本进行了免疫荧光显微镜
In 1970, Baldwin et al. Classified lupus nephritis histologically as type 3 of focal proliferation, diffuse proliferation and membranousity, followed by authors adding minimal mesangial lesion. Although most scholars believe that there are many benign lesions in patients with mild mesangial lupus nephritis, diffuse lupus nephritis and more lead to renal failure, but the prognosis of focal lupus nephritis there are still different views. In strict accordance with the World Health Organization (WHO) classification criteria, from 200 cases of patients with systemic lupus erythematosus who have been renal biopsy, 15 patients (7%) meet the diagnostic criteria of focal segmental lupus nephritis in patients with 2 ~ 20 (average 6.3) years of follow-up observation, and then its histological changes associated with clinical process (proteinuria, hypertension and changes in renal function) for a comprehensive analysis. The 15 cases of 19 renal biopsy specimens and 1 cadaveric renal specimens were examined by light microscopy, of which 17 were also biopsy specimens of renal biopsy samples were electron microscopy, 7 times the renal biopsy specimens were immunofluorescence microscopy