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目的分析河南省儿童吉兰-巴雷综合征(Guillain-Barre Syndrome,GBS)流行病学特征,为儿童GBS病例的管理和预防提供科学参考。方法用描述性分析方法对2004~2015年河南省报告0~14岁儿童GBS病例进行分析。结果 2004~2015年河南省共报告0~14岁儿童GBS病例1 593例,平均发病率为0.69/10万,各年发病率在0.48/10万(95例,2014年)~0.83/10万(152例,2006年)之间(趋势检验,x2=41.16,P=0.000)。各地区发病率在0.29/10万(58例,信阳市)~1.03/10万(15例,济源市)之间。年龄别发病率在0.22/10万(35例,14岁)~1.86/10万(313例,1岁)之间。男、女性发病率分别为0.81/10万、0.54/10万。6~8月份报告506例(31.76%)。GBS病例肠道病毒分离率为13.81%(220/1 593)。401例(25.17%)病例60天后随访有残留麻痹。结论河南省0~14岁儿童GBS发病率呈逐年下降趋势,以小年龄、男性儿童多发,呈夏秋季高峰。需进一步加强儿童GBS监测和残留麻痹病例的早期康复治疗。
Objective To analyze the epidemiological characteristics of Guillain-Barre Syndrome (GBS) in children in Henan Province and provide scientific reference for the management and prevention of childhood GBS. Methods Descriptive analysis was used to analyze GBS cases of children aged 0-14 years from 2004 to 2015 in Henan province. Results A total of 1 593 GBS cases of children aged 0-14 years were reported in Henan Province from 2004 to 2015, with an average incidence rate of 0.69 per 100 000. The incidence rate of each year was 0.48 / 100,000 (95 cases, 2014) to 0.83 / 100,000 (152 cases, 2006) (trend test, x2 = 41.16, P = 0.000). The prevalence rate in each region was 0.29 / 100,000 (58 cases, Xinyang City) ~ 1.03 / 100,000 (15 cases, Jiyuan City). The age-specific morbidity rate was 0.22 / 100,000 (35 cases, 14 years) to 1.86 / 100,000 (313 cases, 1 year). Male and female incidence rates were 0.81 / 100,000, 0.54 / 100,000. 506 cases (31.76%) were reported from June to August. GBS cases of enterovirus isolation rate was 13.81% (220/1 593). 401 cases (25.17%) cases were followed up for 60 days after residual paralysis. Conclusion The incidence of GBS in 0-14-year-old children in Henan province showed a declining trend year by year, with a small age and multiple male children, showing a peak in summer and autumn. There is a need to further strengthen the early rehabilitation of children with GBS monitoring and residual paralysis cases.