Objective To explore the effect of health education promotion among newly married couples who need reproductive health knowledge and service.Methods An intervention study was conducted at three sub-districts, Xuhui district,Shanghai, which aimed to improve reproductive health of newly married couples. The main intervention activities included creating educational web pages, organizing participatory activities, distributing leaflets, and providing relevant counseling and technique service.Results After intervention, the knowledge of family planning and reproductive health and their sanitary habit for these newly married couples were much improved.Conclusion This project produced a model to improve reproductive health at sub-district level and this model can be expanded to provide relevant service to other groups of people.