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目的:探讨穿琥宁注射剂引起血小板减少的特点和诱发因素。方法:通过检索1994-2004年国内医药学期刊,收集穿琥宁注射剂致血小板减少病案62例,应用文献计量学方法对病历的资料进行整理与归纳。结果:男性33例(53.2%),女性29例(46.8%);其中<18岁的未成年患者31例,占53.4%;均为常规剂量静脉滴注给药;不良反应多发生在用药后2～6d(44.2%)。结论:。掌握穿琥宁致血小板减少的特点将有助于该药的安全使用。
Objective: To investigate the characteristics and predisposing factors of thrombocytopenia caused by Chuanhuning injection. Methods: 62 cases of thrombocytopenia caused by Chuanhuning injection were collected by searching the domestic medical journals from 1994 to 2004. Bibliometric methods were used to sort and summarize the medical records. Results: 33 cases (53.2%) were males and 29 cases (46.8%) were females. Among them, 31 cases (<53.4%) were young patients <18 years of age; all were given intravenous infusion at regular doses; adverse reactions occurred mostly after administration. 2 to 6 days (44.2%). in conclusion:. Mastering the characteristics of thrombocytopenia induced by Chuanhuning will contribute to the safe use of the drug.