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目的 :评价鼻咽癌咽旁间隙受侵不同照射野放射治疗的疗效。方法 :收集 1993年 1月— 1995年 12月经病理确诊、CT扫描证实有咽旁侵犯的鼻咽癌 34 8例 ,按放射治疗设野不同分为面颈联合野组和耳前野组 ,对 5年生存率、局控率、无远处转移生存率和急慢性放射损伤进行分析和评价。结果 :面颈联合野组 5年生存率高于耳前野组 (P<0 .0 5 ) ,面颈联合野组 5年局控率明显高于耳前野组 (P<0 .0 1) ,咽旁后间隙受侵面颈联合野组 5年生存率高于耳前野组 (P<0 .0 5 ) ,咽旁前间隙受侵 5年生存率两组比较无明显差异 (P>0 .0 5 ) ,面颈联合野组发生放射性咽炎、口干反应明显高于耳前野组 (P<0 .0 1) ,放射性脊髓炎、放射性脑病两组比较差异无显著性 (P>0 .0 5 )。结论 :鼻咽癌咽旁后间隙受侵应选用面颈联合野放射治疗
Objective: To evaluate the efficacy of radiotherapy in different irradiation fields of nasopharyngeal space in nasopharyngeal carcinoma. Methods: A total of 348 cases of nasopharyngeal carcinoma confirmed by pathology and confirmed by CT scan from January 1993 to December 1995 were collected and divided into 5 groups: facial and neck combined field group and preecustopic group according to radiation field, Annual survival rate, local control rate, distant metastasis-free survival rate and acute and chronic radiation injury were analyzed and evaluated. Results: The 5-year survival rate of face-neck combined field group was higher than that of pre-antero-forelimb group (P <0.05). The 5-year local control rate of face-neck combined field group was significantly higher than that of anterior group (P <0.01) The 5-year survival rate of the combined group was significantly higher than that of the anterior group (P <0.05), while the 5-year survival rate of the anterior parapharyngeal space was no significant difference between the two groups (P> 0.05). 0 5). Radiation pharyngitis occurred in the face-neck joint field group, and the dry mouth reaction was significantly higher than that in the anterior group (P <0.01). There was no significant difference between the two groups in radiation encephalomyelitis and radiation encephalopathy (P> 0.05) 5). Conclusion: nasopharyngeal carcinoma after parapharyngeal space invasion should be selected face-neck joint field radiation therapy