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背景有关妊娠期母亲的营养和微量营养素状况,及其后代发生呼吸疾病问题越发得到了关注。目的 调查妊娠期母亲贫血与婴幼儿喘鸣及哮喘的相关性。方法 研究人群,经妊娠期跟踪至孩子6岁再接触对女性的孩子做呼吸健康评估。将分娩住院期间母亲贫血诊断及血红素(Hgb)<11评估为暴露。研究结果包括婴幼儿喘鸣;从出生至6岁各型喘鸣(早发一过性喘鸣,迟发喘鸣,早发持续喘鸣);及儿童期哮喘的诊断。结果 有11.9%的母亲有贫血报告,第1年反复发生新生儿喘鸣[校正优势比(ORa)=2.17,95%CI(1.18,4.00)]、3岁前喘鸣[ORa=2.42,95%CI(1.38,4.23)]、及早发一过性喘鸣和早发各型喘鸣[分别为:ORa=2.81,95%CI(1.38,5.72)及ORa=2.07,95%CI(1.02,4.22)]。母亲患哮喘儿童中,母亲贫血与第1年反复发生喘鸣[ORa=4.22,95%CI(1.65,10.80)]及3岁前喘鸣[ORa=2.73,95%CI(1.17,6.35)]关联。母亲患哮喘增加了后代哮喘诊断[ORa=2.53,95%CI(1.04,6.17)]及发生哮喘[ORa=3.46,95%CI(1.45,8.26)]的几率。结论 妊娠期母亲贫血与婴儿呼吸健康结果关联。若本观察具有可重复性,母亲贫血应成为干预及进一步研究的靶目标。
Background Concerns about the nutritional and micronutrient status of mothers during pregnancy, and the problems of respiratory disease in their offspring have drawn increasing attention. Objective To investigate the correlation between maternal anemia in pregnancy and wheezing and asthma in infants and young children. METHODS: The population was studied, followed by gestational age until the child was 6 years of age and then exposed to a respiratory assessment of the child’s health. Maternal anemia diagnosis and heme (Hgb) <11 during childbirth during hospitalization were assessed as exposure. The findings include wheezing in infants and young children; various types of wheezing (early onset transient wheezing, delayed wheezing, early sustained wheezing) from birth to 6 years of age; and diagnosis of childhood asthma. Results Anemia was reported in 11.9% of mothers and neonatal wheezing recurred in year 1 (adjusted odds ratio (ORa = 2.17, 95% CI 1.18, 4.00)], wheezing before age 3 [ORa = 2.42, 95 % CI (1.38, 4.23)], early onset of transient wheezing and early onset of various types of wheezing [ORa = 2.81,95% CI 1.38,5.72 and ORa 2.07,95% CI 1.02, 4.22)]. Mothers with asthma had anemia with repeated wheezing during the first year (ORa = 4.22, 95% CI 1.65, 10.80) and wheezing 3 years before (ORa = 2.73, 95% CI 1.17, 6.35) Associated. Maternal asthma increased the risk of developing offspring asthma diagnosis [ORa = 2.53, 95% CI (1.04, 6.17)] and asthma [ORa = 3.46, 95% CI (1.45, 8.26)]. Conclusion Maternal anemia in pregnancy is associated with respiratory health outcomes in infants. If this observation is reproducible, maternal anemia should be the target of intervention and further study.