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目的对比分析ABO血型不合异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,alloHSCT)后的血型变化,以及移植后输血方法,为患者输入合适的血液提供有效的依据。方法选取2015年4月—2016年4月经不合allo-HSCT后患者32例,在移植后检测患者ABO血型抗原以及抗体,并与同期26例血型相合的alloHSCT患者血型情况比较。结果 ABO血型主要不合异基因的患者,在移植手术后,血型抗原转变为提供者血型后,检测血型配对成功,ABO血型次要不合异基因的患者与ABO主要不合异基因的患者,在移植手术后,检测血型,可出现血型配对不成功以及ABO主要血型不合异基因移植在血型转换之后,患者血型检测与正反定型相符,证明患者与提供者血型配对成功。结论 ABO血型不合异基因干细胞移植后,患者与提供者血型配对成功,并且成功改变血型,所以选择相对应的血液进行输血,以确保临床上输血治疗安全性以及有效性。
Objective To compare the blood group changes after allogeneic hematopoietic stem cell transplantation (alloHSCT) with ABO blood transfusion and the transfusion method after transplantation to provide an effective basis for the patients to enter the appropriate blood. Methods Thirty-two patients who underwent uno-HSCT between April 2015 and April 2016 were enrolled in this study. ABO blood group antigens and antibodies were detected after transplantation and were compared with those of 26 patients with alloHSCT. Results In patients with ABO major non-allogeneic patients, after blood transfusion surgery, the blood group antigen was changed to donor blood group, the blood group pairing was successful, the patients with ABO blood group minor non-specific genes and the patients with ABO major non- After the detection of blood type, there may be unsuccessful pairing of blood type and ABO major blood group incompatible allogeneic transplantation after the blood type conversion, the patient’s blood type test is consistent with the positive and negative stereotypes, which prove that the pairing of the blood type of the patient and the provider is successful. Conclusion ABO incompatible allogeneic stem cell transplantation, the patient and provider of blood group pairing success, and the successful change of blood type, so choose the corresponding blood transfusion, in order to ensure the safety and effectiveness of transfusion therapy in clinical.