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The antitumor activity of 5 fluorouracil 1 acetic acid(HFAA) and its lanthanide complexes(La(FAA) 3, Eu(FAA) 3) were studied. The results show that HFAA, La(FAA) 3 and Eu(FAA) 3 with the concentrations of 1 0×10 -5 ～1 0×10 -2 μg·ml -1 inhibit the colony formation of leukemia cells(L 1210 ) and the growth of transplanted tumor sarcoma 180(S 180 ), hepatic carcinoma(HEPA) and ehrlich ascites tumor(EC) as well. The maximum inhibitory rate of Eu(FAA) 3 for S 180 is 38 4%, that HFAA and La(FAA) 3 for EC are 22 4% and 43 4%, respectively. The life prolongation rate of Eu(FAA) 3 for HEPA bearing mice is as long as 284%.
The antitumor activity of 5 fluorouracil 1 acetic acid (HFAA) and its lanthanide complexes (La (FAA) 3, Eu (FAA) 3) were studied. The results show that HFAA, La (FAA) 3 and Eu the concentrations of 1 × 10 -5 to 1 × 10 -2 μg · ml -1 inhibit the colony formation of leukemia cells (L 1210) and the growth of transplanted tumor sarcoma 180 (S 180), hepatic carcinoma (HEPA) The maximum inhibitory rate of Eu (FAA) 3 for S 180 is 38 4%, that of HFAA and La (FAA) 3 for EC are 22 4% and 43 4%, respectively. The ehrlich ascites tumor (EC) as well. life prolongation rate of Eu (FAA) 3 for HEPA bearing mice is as long as 284%.