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Objective:To investigate the expression lose rates of two kinds different RASSF1 transcripts RASSF1A,RASSF1B in gastric-carcinoma and benign gastric disease and discuss their relations to clinical significance.Methods:The mRNA expressions of RASSF1A and RASSF1B were detected by RT-PCR in 32 patients with gastric-carcinoma,32 with adjacent non-carcinomatous gastric tissues and 51 cases with benign gastric disease (include 30 chronic shallow gastritis and 21 chronic atrophic gastritis).Results:The rates of expression loss of transcripts A and B in gastric-carcinoma were 59.3% (19/32) and 28.2% (9/32),10% (3/30) and 6.7% (2/30) in chronic shallow gastritis (CSG),28.6% (6/21) and 14.3% (3/21) in chronic atrophic gastritis (CAG),respectively.The rates of expression loss of transcripts A and B in adjacent noncarcinomatous were 0.RASSF1A and RASSF1B mRNA expressions had no statistical relations with different grade of gastriccarcinoma.Conclusion:The two different RASSF1 transcripts RASSF1A and RASSF1B were almost expressed in adjacent non-carcinomatous gastric tissues.RASSF1A had a significant expression loss in gastric-carcinoma,and has no statistical relation with different grade of gastric-carcinoma.The result indicated that RASSF1A was a suppressor gene.