心血管系统异位钙化是与临床心血管疾病密切相关的一种病理改变 ,主要发生于动脉血管壁及心脏瓣膜 ,可增加急性心肌梗死、血管成形术后内膜撕裂等严重临床事件的发生 ,是心血管疾病发生率及死亡率的预测因素。它与生理性骨化过程类似 ,是一个主动的、可调节的过程 ,基质Gla蛋白、骨形态发生蛋白及骨桥蛋白等参与此过程的调节。 Ectopic calcification of the cardiovascular system is a pathological change closely related to clinical cardiovascular disease, mainly occurs in the arterial wall and heart valves, which can increase the occurrence of serious clinical events such as acute myocardial infarction and intimal tear after angioplasty , Is a predictor of cardiovascular morbidity and mortality. Similar to physiological ossification process, it is an active and regulative process. Matrix Gla protein, bone morphogenetic protein and osteopontin participate in this process.