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局部晚期膀胱癌的临床行为难以预料.现今对临床行为进行预测一般有以下几项指标:肌侵犯深度,出现血管侵犯,肿瘤增殖速度及血型分型抗原消失.发展新的可靠的肿瘤演进标志物对促进临床治疗方案的选择大有帮助.已报道功能性RB基因丢失在膀胱癌中出现,但这种丢失的重要意义尚未明了.作者在本文中对局部晚期膀胱癌中RB基因功能的丢失频率做了评价,并将这一丢朱结果与其它已知的膀胱癌预后指标进行了比较.
The clinical behavior of locally advanced bladder cancer is unpredictable.Nowadays, the prediction of clinical behavior generally includes the following indicators: the depth of muscle invasion, vascular invasion, the rate of tumor proliferation and the disappearance of the blood grouping type antigens.Development of a new and reliable marker of tumor evolution Which has been instrumental in promoting the choice of clinical regimen. The loss of functional RB genes has been reported in bladder cancer, but the significance of this loss is not yet known. In this article, we examined the frequency of RB gene loss in locally advanced bladder cancer Made an evaluation and compared the result of this drop with other known prognostic indicators of bladder cancer.