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附睾是男性生殖系统的重要器官之一,负责精子的成熟、转运和储存。附睾功能的实现依赖于其旺盛的生理活性,因而自由基的产生不可避免。自由基过度积累势必造成附睾氧化应激,精子质膜及其DNA发生氧化损伤,极大影响精子运动和受精能力的获得,从而造成男性不育。本文对附睾氧化应激在能量代谢、炎症反应等过程中的产生机制和超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化酶、吲哚胺双加氧酶、还原性谷胱甘肽及硫氧还蛋白等物质的抗氧化作用进行了综述,以期为男性不育症的有效预防、诊断和治疗提供新思路。
Epididymis is one of the important organs of the male reproductive system, responsible for the sperm maturation, transport and storage. The realization of epididymal function depends on its strong physiological activity, so the generation of free radicals is inevitable. Over-accumulation of free radicals will inevitably lead to epididymal oxidative stress, oxidative damage of sperm plasma membrane and DNA, greatly affecting the acquisition of sperm motility and fertilization, resulting in male infertility. In this paper, epoxidation of epoxidation of oxidative stress in the process of energy metabolism, inflammation and other mechanisms of production and superoxide dismutase, catalase, glutathione peroxidase, indoleamine dioxygenase, reductive glutathione Glycyrrhizin and thioredoxin and other substances were reviewed in order to provide new ideas for the effective prevention, diagnosis and treatment of male infertility.