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目的:优选和胃消痞合剂的最佳制备工艺。方法:采用正交试验法,分别以芍药苷的含量和醇浸膏量为量化指标,优选水提醇沉和乙醇提取的最佳提取工艺。结果:最佳水提醇沉工艺为A1B3C2D2,即药材加10倍量的水,煎煮2次,每次1.5h,醇沉浓度为70%;醇提工艺最优方案为A1B3C2D1,即药材加6倍量70%的乙醇,浸泡0.5h,回流提取3次,时间分别为1.5,1,1h。结论:经正交设计优化的和胃消痞合剂的制备工艺可行。
Objective: To optimize the preparation process of Weixiao Pian Mixture. Methods: Using orthogonal test method, the content of paeoniflorin and the amount of alcohol extract were quantified, respectively, and the best extraction process was ethanol extraction. Results: The best water extraction and alcohol precipitation process for the A1B3C2D2, that is, herbs and 10 times the amount of water, boiling 2 times, each 1.5h, alcohol sedimentation concentration of 70%; alcohol extraction process for the optimal program A1B3C2D1, 6 times the amount of 70% ethanol, soak 0.5h, reflux extraction three times, respectively, 1.5,1,1 h. Conclusion: The orthogonal design and the preparation of Weixiao Xiaopi mixture feasible.