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设计了用于硫酸庆大霉素脱色工艺的活性炭纤维(ACF)吸附塔(径高比为1∶4),进行动态吸附脱色和活化再生的中试研究,并考察中试工艺对成品质量的影响。结果表明,选用具有较高比表面积(2 000 m2/g)的ACF、装填2 kg的吸附塔,活化再生45次后吸附能力仍能达到初始吸附能力的80%。采用本中试工艺和现有767型药用活性炭脱色工艺分别处理平均效价为2.5×105u/ml的庆大霉素转盐液2.25 m3,中试工艺的活性炭纤维累积单耗3.56 g/(1×109u),所得产品符合中国药典2010年版,而现有工艺的活性炭平均单耗为1 kg/(1×109u)。
The ACF adsorption tower (diameter to diameter ratio of 1: 4) for the gentamycin sulfate decolorization process was designed for the pilot study of dynamic adsorption decolorization and activated regeneration. The effects of pilot process on the quality of the finished product influences. The results showed that adsorption capacity of 2 kg of ACF with a higher specific surface area (2 000 m2 / g) and an adsorption capacity of 80% after initial regeneration 45 times could still reach 80% of initial adsorption capacity. The pilot-scale process and the existing 767 medicinal activated carbon decolorization process were respectively used to treat 2.25 m3 of gentamicin salt-changing liquid with an average titer of 2.5 × 105u / ml. The cumulative consumption of activated carbon fiber in the pilot-scale process was 3.56 g / ( 1 × 109u). The obtained product conforms to the 2010 edition of Chinese Pharmacopoeia, while the average consumption of activated carbon in the existing process is 1 kg / (1 × 109u).