糖尿病是一极其古老的病种,从有可靠文字的史料记载至今,至少已经有3500年以上的历史了。然而人们对这一疾病的认识,却始终处于扑朔迷离的状态之中。直到近80年来,才逐步撩开了她神秘的面纱,触摸到她跳动的脉搏-胰岛素分泌缺陷和胰岛素抵抗所导致的一种以高血糖为特征、跨学科、多系统的代谢综合征。1胰岛素分泌缺陷-绝对缺乏与相对缺乏的辨证统一:所谓的绝对缺乏是指由于免疫介导的β细胞损伤导致胰岛素绝对缺乏,它通常是引起1型糖尿病发病的原因,在这一破坏进程的最开始阶段,主要是有细胞因子来介导的,是一个依赖巨 Diabetes is an extremely ancient disease that has been recorded for at least 3,500 years from a reliable source of historical records. However, people’s understanding of this disease has always been in a complicated and confusing state. It was not until 80 years ago that she gradually opened her mysterious veil and touched her pulsating pulse - a hyperglycemic, interdisciplinary, multisystem metabolic syndrome caused by insulin-producing defects and insulin resistance. 1 Insulin Secretion Defects - Syndrome Differentiation of Absolute Deficiency and Relative Deficiency: The so-called Absolute Deficiency refers to the absolute lack of insulin due to immune-mediated beta-cell injury and is usually responsible for the onset of type 1 diabetes. In this process of disruption The initial stage, mainly cytokine-mediated, is a dependent giant