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肠道除具有消化吸收及蠕动功能外,还有激素分泌、免疫调节和黏膜屏障功能,肠黏膜屏障在维护肠功能中扮演着重要角色。大量的临床和实验研究发现,多种因素能够削弱或破坏肠黏膜屏障功能,进而诱发细菌移位和内毒素血症。本文就近年来对肠黏膜屏障功能障碍发生机制的研究进展作一综述。
In addition to intestinal digestion and absorption and peristalsis function, but also hormone secretion, immune regulation and mucosal barrier function, intestinal mucosal barrier in the maintenance of intestinal function plays an important role. A large number of clinical and experimental studies have found that a variety of factors can weaken or destroy the barrier function of the intestinal mucosa, thereby inducing bacterial translocation and endotoxemia. This review summarizes recent research progress on the mechanism of intestinal mucosal barrier dysfunction.