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背景与目的病理学检查为肺癌诊断的“金标准”,然而关于各种标本的细胞病理学检查在肺癌诊断中作用的文献报道较少。本研究拟探讨细胞病理学检查在原发性支气管肺癌诊断中的价值。方法回顾性分析我院2003年1月~2005年5月经病理确诊的原发性支气管肺癌248例患者共552份各种标本的细胞病理学检测结果,对胸液、肺穿刺物、支气管刷检物涂片、支气管肺泡灌洗液和痰液等标本的细胞病理学进行总结分析。结果552份胸液、肺穿刺物、支气管刷检物、支气管肺泡灌洗液和痰液标本的细胞病理学检查阳性率分别为69.12%、67.74%、65.22%、23.08%和21.19%。胸液、支气管刷检物和肺穿刺物的阳性率显著高于支气管肺泡灌洗液和痰液(P<0.01),而胸液、支气管刷检物和肺穿刺物之间,支气管肺泡灌洗液与痰液之间的阳性率无显著性差异(P>0.05)。结论细胞病理学检查对原发性支气管肺癌的诊断具有一定的指导意义,为原发性支气管肺癌的确诊途径之一。
BACKGROUND & OBJECTIVE: Pathological examination is the “golden standard” for the diagnosis of lung cancer. However, there are few reports about the role of cytopathology in various kinds of specimens in the diagnosis of lung cancer. This study was to investigate the value of cytopathology in the diagnosis of primary bronchogenic carcinoma. Methods A retrospective analysis of our hospital from January 2003 to May 2005 by pathology of 248 patients with primary bronchogenic carcinoma of lung cancer were a total of 552 specimens of various types of cytopathology test results, pleural effusion, lung biopsy, bronchial brushing Smear, bronchoalveolar lavage fluid and sputum and other specimens of the cytopathology were analyzed. Results The positive rates of cytopathology in 552 pleural effusion, pulmonary aspirate, bronchial brush, bronchoalveolar lavage and sputum were 69.12%, 67.74%, 65.22%, 23.08% and 21.19%, respectively. The positive rates of pleural effusion, bronchial brushing test and pulmonary aspirate were significantly higher than those of bronchoalveolar lavage and sputum (P <0.01), while those of pleural effusion, bronchial brush test and pulmonary aspirate, bronchoalveolar lavage No significant difference was found between the positive rate of fluid and sputum (P> 0.05). Conclusions Cytopathology examination is of guiding significance for the diagnosis of primary bronchogenic carcinoma and is one of the diagnostic methods for primary bronchogenic carcinoma.