论文部分内容阅读
目的:探讨替勃龙联合心理干预对围绝经期综合征妇女血清促卵泡素(FSH)和雌二醇(E_2)水平的影响。方法:72例围绝经期综合征患者分为观察组和对照组各36例。两组患者均予替勃龙片2.5 mg,po,qd,观察组同时予以综合性心理干预,两组疗程均为8周。比较两组治疗前后血清FSH和E_2平的变化,观察两组临床疗效。结果:治疗8周后,两组患者FSH水平明显下降,E_2水平明显上升(P<0.05或0.01),且观察组下降或上升值明显高于对照组(P<0.05)。观察组总有效率91.67%明显优于对照组的66.67%(P<0.01)。结论:替勃龙联合心理干预治疗围绝经期综合征的具有良好的临床疗效,作用机制与其能降低血清FSH水平,提高E_2水平,纠正患者的内分泌功能紊乱密切相关。
Objective: To investigate the effects of tibolone and psychological intervention on serum levels of follicle stimulating hormone (FSH) and estradiol (E 2) in women with perimenopausal syndrome. Methods: 72 patients with perimenopausal syndrome were divided into observation group and control group, 36 cases each. Two groups of patients were given tibolone tablets 2.5 mg, po, qd, the observation group at the same time to be a comprehensive psychological intervention, two courses of treatment were 8 weeks. The changes of serum FSH and E2 levels before and after treatment were compared between two groups to observe the clinical curative effect. Results: After 8 weeks of treatment, the level of FSH in both groups decreased significantly, the level of E_2 increased significantly (P <0.05 or 0.01), and the decrease or increase in observation group was significantly higher than that in control group (P <0.05). The total effective rate in observation group was 91.67%, which was significantly higher than that in control group (66.67%, P <0.01). Conclusion: Tibolone combined with psychological intervention in the treatment of perimenopausal syndrome has a good clinical efficacy, its mechanism of action and its ability to reduce serum FSH levels, improve E 2 levels, to correct the patient’s endocrine disorders are closely related.