目的探讨利培酮对精神分裂症患者血清细胞因子的影响。方法对３９例精神分裂症患者给予利培酮治疗６周，在治疗前后检测血清ＩＬ－６， ＩＬ－８， ＩＦＮ－ｒ和ＴＮＦ－ａ水平，并采用ＰＡＮＳＳ量表和ＴＥＳＳ量表评估临床症状和药物副反应。结果利培酮治疗后，血清ＩＬ—６水平显著下降，治疗前血清ＩＬ—６水平与ＰＡＮＳＳ阳性因子分显著正相关，而血清ＩＬ—６减分率与药物最高剂量呈显著正相关，血清ＩＬ－８，ＩＦＮ－ｒ和ＴＮＦ－ａ水平变化不显著。结论精神分裂症精神症状可能与细胞因子的功能异常有关，利培酮可能因抑制ＩＬ－６的生成而起到免疫抑制作用。 Objective To investigate the effect of risperidone on serum cytokines in schizophrenia patients. Methods 39 patients with schizophrenia were treated with risperidone for 6 weeks. The serum levels of IL-6, IL-8, IFN-γ and TNF-α were measured before and after treatment. The clinical symptoms were assessed by PANSS and TESS And drug side effects. Results After treatment with risperidone, serum IL-6 level was significantly decreased. Serum IL-6 level before treatment was positively correlated with PANSS positive factor, while the serum IL-6 reduction rate was positively correlated with the highest dose of drug. Serum IL -8, IFN-r and TNF-a levels did not change significantly. Conclusions The psychiatric symptoms of schizophrenia may be related to the abnormal function of cytokines. Risperidone may play an immunosuppressive role by inhibiting the production of IL-6.