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目的 探讨镁 (Mg2 + )对缺氧缺血性脑损伤的神经保护作用及其与神经细胞凋亡的关系。方法 结扎新生 7日龄Wistar大鼠左颈总动脉后吸入 8%浓度氧 2h制成标准化动物模型 ,72h后断头取脑。用原位末端标记技术和苏木素 伊红染色分别对对照组、缺氧缺血组和硫酸镁治疗组动物脑组织中凋亡细胞数量和脑组织神经病理改变进行观察比较。结果 缺氧缺血后脑组织内末端标记阳性的凋亡细胞明显增加 (t =- 5 6 6 1,P <0 0 0 1) ,神经细胞变性显著。硫酸镁治疗组标记阳性的细胞数比同时间的缺氧缺血组显著降低 (t =10 36 ,P <0 0 0 1) ,神经细胞变性坏死减少。结论 镁对新生鼠缺氧缺血性脑损伤有保护作用 ,其作用与抑制细胞凋亡有关。
Objective To investigate the neuroprotective effect of magnesium (Mg2 +) on hypoxic-ischemic brain damage and its relationship with neuronal apoptosis. Methods The left common carotid artery of 7-day-old Wistar rats was ligated with 8% oxygen for 2 hours to make a normal animal model. After 72 hours, the brain was decapitated. The number of apoptotic cells and neuropathological changes in brain tissue of the control group, hypoxic-ischemia group and magnesium sulfate-treated group were observed and compared by in situ end-labeling and hematoxylin-eosin staining respectively. Results The number of apoptotic positive cells in the end of Hypoxic - ischemic brain tissue was significantly increased (t = - 5661, P <0.01), and the degeneration of neurons was significant. The number of positive cells in the magnesium sulfate treatment group was significantly lower than that in the hypoxia-ischemia group (t = 10 36, P 0 01), and the degeneration and necrosis of the nerve cells decreased. Conclusion Magnesium has a protective effect on neonatal rats with hypoxic-ischemic brain damage and its effect is related to the inhibition of apoptosis.