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为评价新三嗪类抗球虫药物纳川珠利的安全性,选用100只昆明小鼠,连续30d分别灌服4.8、19.2、76.8mg/kg的药物,以纯水和空白溶剂为对照,通过临床观察、血液学分析、血液生化检测、脏器系数和病理学检查,系统地评估了该化合物对小鼠的亚急性毒性作用。结果显示,试验期间无小鼠死亡,在开始用药1周内,高剂量组小鼠有轻微临床毒性症状,2周后症状消失。试验过程中各组小鼠增重差异无统计学意义(P>0.05),长期高剂量给药后小鼠心和肝的脏器系数明显改变(P<0.05),血液红细胞、碱性磷酸酶、肌酐明显增高和葡萄糖、胆固醇、尿酸显著降低(P<0.05),高剂量组肝、肾小部分发生轻微水样变性、点状坏死等病理改变,停药15d后,碱性磷酸酶和尿酸水平与对照组差异有统计学意义(P<0.05)。提示纳川珠利长期大剂量使用可能存在肝、肾等轻微损伤的风险,但损伤是可逆的,停药后短期可逐渐恢复,临床使用相对安全。
In order to evaluate the safety of NAC, a new triazine anti-coccidiosis drug, 100 Kunming mice were selected and administrated with 4.8, 19.2 and 76.8 mg / kg of drugs for 30 days continuously. Pure water and blank solvent were used as controls, The subacute toxic effects of the compound on mice were systematically evaluated by clinical observation, hematological analysis, blood biochemical detection, organ coefficient and pathological examination. The results showed that no mice died during the test period, the mice in the high dose group had slight clinical toxicity within one week after starting the medication, and the symptoms disappeared after two weeks. There was no significant difference in the weight gain of mice in each group during the experiment (P> 0.05). After long-term high-dose administration, the organ coefficients of heart and liver in mice were significantly changed (P <0.05). The levels of erythrocyte, alkaline phosphatase , Creatinine significantly increased, and glucose, cholesterol and uric acid were significantly decreased (P <0.05). In the high-dose group, slight watery degeneration and spot-like necrosis occurred in small parts of liver and kidney, and after 15 days of withdrawal, alkaline phosphatase and uric acid There was significant difference between the levels and the control group (P <0.05). It is suggested that Nachikangzhuli may have the risk of mild injury such as liver and kidney in long-term high-dose, but the injury is reversible. After stopping the medicine, it can be recovered in a short period and the clinical use is relatively safe.