论文部分内容阅读
目的 :分析慢性肝病患者血清HA、LN、Ⅳ C、PCⅢ水平与临床分型及病理分期的关系。方法 :对 2 0 0例慢性肝病患者 (其中 98例采用肝活检确诊 )分别采用放免法测定血清HA、LN、Ⅳ C、PCⅢ水平。结果 :血清HA、LN、Ⅳ C、PCⅢ水平在慢性肝炎中度和病理S3期时开始明显高于对照组 (P <0 .0 5 ) ,但PCⅢ水平在病理S2 期就开始明显高于对照组 (P <0 .0 5 ) ,且随着肝脏炎症和纤维化程度的加重而升高。结论血清HA、LN、Ⅳ C、PCⅢ水平可反映肝纤维化程度 ,而且受肝脏炎症程度的影响。PCⅢ似是判断早期肝硬化的相对灵敏和可靠指标。
Objective: To analyze the relationship between serum levels of HA, LN, Ⅳ C and PCⅢ in patients with chronic liver disease and their clinical classification and pathological stage. Methods: Serum levels of HA, LN, Ⅳ C and PCⅢ were determined by radioimmunoassay in 200 cases of chronic liver disease (98 cases were diagnosed by liver biopsy). Results: Serum levels of HA, LN, IV C and PCⅢ were significantly higher in patients with moderate chronic hepatitis and S3 in the pathological stage than those in the control group (P <0.05), but PCⅢ levels were significantly higher in S2 Group (P <0.05), and increased with the severity of liver inflammation and fibrosis. Conclusion The levels of serum HA, LN, Ⅳ C and PCⅢ can reflect the degree of liver fibrosis and are affected by the severity of liver inflammation. PC Ⅲ seems to determine the relative sensitivity and reliability of early cirrhosis.