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结节红斑的病因有多种,过去认为与结核、肉样瘤病和溶血性链球菌有关,而以后一种常见,但仍有1/3病例病因不明。作者报告54例结节红斑,根据临床和多项免疫学检查,有31例能查明原因,其中12例为化脓链球菌感染,8例为耶氏肠道杆菌(Yersinia Enterocolitica,YE)此两者占大多数,其它有肉样瘤病4例,结核、Crohn氏病、口服避孕药各2例,妊娠1例。本组8例由YE引起的结节红斑之依据为YE血清凝集试验阳性,共检查21例,阳性率占38%。作者复习文献报告的227例,指出YE作为结节红斑的病因在欧洲大陆尤其是北欧多见,如瑞典占20%,芬兰占10～17%。
There are many causes of erythema nodosum, in the past that with tuberculosis, sarcoidosis and hemolytic streptococcus, but after a common, but still 1/3 of the etiology is unknown. The authors report 54 cases of erythema nodosum on 31 clinical and immunologic examinations, of which 12 were confirmed by Streptococcus pyogenes and 8 by Yersinia Enterocolitica (YE) Among them, there were 4 cases with sarcoidosis, 2 cases with tuberculosis, Crohn’s disease, oral contraceptives and 1 case with pregnancy. The group of 8 cases of erythema caused by YE nodules on the basis of YE serum agglutination test was positive, a total of 21 cases were examined, the positive rate was 38%. The authors reviewed 227 reports of the literature, noting that the etiology of YE as erythema of the nodules is more common in continental Europe, especially in northern Europe, with Sweden accounting for 20% and Finland accounting for 10-17%.