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目的通过荟萃分析探讨中国老年人群冠心病发生与血尿酸水平的关系。方法从中国生物医学文献数据库和Pubmed等外文专业数据库中收录的1998年1月1日至2009年12月31日有关中国老年人群冠心病和尿酸水平相关分析文献中,纳入符合条件的文献,应用CHISS软件进行荟萃分析。结果针对中国老年人群进行的冠心病和血尿酸水平分析的研究存在异质性,荟萃分析得到尿酸水平与老年冠心病发生95%可信区间为-20.2248～31.7392,差异无统计学意义。结论荟萃分析未见中国老年人血尿酸升高与冠心病发生之间存在相关关系,多中心随机对照试验研究有望得到有关这一特定人群血尿酸水平与冠心病发生关系的确凿证据。
Objective To investigate the relationship between coronary heart disease and serum uric acid level in Chinese elderly population by meta-analysis. Methods From the Chinese Biomedical Literature Database and Pubmed and other foreign professional databases from January 1, 1998 to December 31, 2009 in Chinese elderly population coronary heart disease and uric acid level related literature, the inclusion of eligible documents, application CHISS software for meta-analysis. Results There was heterogeneity in the analysis of coronary heart disease and serum uric acid level in Chinese elderly population. The meta-analysis showed that the 95% confidence interval of uric acid level and elderly coronary heart disease ranged from -20.2248 to 31.7392, with no significant difference. Conclusions There is no correlation between elevated serum uric acid and coronary heart disease in the Chinese population in the meta-analysis. The randomized, multicenter controlled trial is expected to provide conclusive evidence about the relationship between serum uric acid level and coronary heart disease in this particular population.