组胺是一种重要神经递质／调质,中枢组胺能神经纤维在脑内投射广泛。组胺有H1、H2、H3、H4四种受体,其中H3受体是Arrang等在1983年首次发现的。近年来的研究发现H3受体在脑内分布广泛,具有多种生物学效应,发挥多种生理功能,与多种神经系统疾病有关。下面就组胺H3受体与神经系统疾病关系的研究进展进行简要介绍。 Histamine is an important neurotransmitter / quencher, and central histaminergic nerve fibers are widely projected in the brain. Histamine H1, H2, H3, H4 four receptors, H3 receptor which was first discovered in 1983 by Arrang et al. In recent years, the study found that H3 receptors are widely distributed in the brain, with a variety of biological effects, play a variety of physiological functions, and a variety of nervous system diseases. The following histamine H3 receptors and the relationship between nervous system disease research progress is briefly introduced.