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聚腺苷二磷酸核糖聚合酶在失血性休克、内毒素性休克和感染性休克,以及机体主要脏器缺血再灌注后激活,参与休克和缺血再灌注损伤的病理过程。抑制聚腺苷二磷酸核糖聚合酶对休克和缺血再灌注损伤有良好的防治作用。
Polyadenosine diphosphate ribose polymerase is involved in the processes of hemorrhagic shock, endotoxic shock and septic shock, as well as the activation of major organs after ischemia-reperfusion, and is involved in the pathological process of shock and ischemia-reperfusion injury. Inhibition of poly ADP-ribose polymerase has a good preventive and therapeutic effect on shock and ischemia-reperfusion injury.