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前列腺癌是威胁男性健康的主要恶性肿瘤之一,近年来其发病率呈上升趋势。前列腺癌的发生是遗传学因素和表观遗传因素共同作用的结果。本文简要综述了PcG(polycomb group)蛋白质、AR共调节子和微RNA(microRNA)等表观遗传修饰方式与前列腺癌的联系,希望有助于前列腺癌的诊断和治疗。
Prostate cancer is one of the major malignant tumors that threaten men’s health. Its incidence has been on the rise in recent years. Prostate cancer is the result of both genetic and epigenetic factors. This review summarizes the links between epigenetic modifications such as PcG (polycomb group) proteins, AR co-regulators and microRNAs (PCNAs) and prostate cancer in the hope of contributing to the diagnosis and treatment of prostate cancer.