前列腺素E具有细胞介导的骨形成和骨吸收作用:它能刺激成骨细胞分裂,产生骨基质,增加破骨细胞数量、大小和刷状缘,加快骨动员。全身用药可增加骨量;对骨施加机械应力可在局部产生前列腺素,诱发塑型和重建。损伤和炎症可使局部组织中前列腺素增加,有助于骨愈合。本文利用狗胫骨损伤模型,对前列腺素在骨愈合过程中的作用进行组织形态定量研究。实验用不同年龄的犬22只,左胫骨中点钻孔(直径5mm),钻孔近端2mm处取厚8mm横切骨状标本,对侧相应部位作为对照。前列腺素投药方法分为口服和 Prostaglandin E has cell-mediated bone formation and bone resorption: it stimulates osteoblasts to divide, produce bone matrix, increase the number, size and brush border of osteoclasts, and accelerate mobilization of bone. Systemic medications increase bone mass; applying mechanical stress to the bone produces prostaglandins locally, inducing plasticity and remodeling. Damage and inflammation can increase the prostaglandins in the local tissue and help to heal the bone. In this paper, we used dog tibial injury model to study the effect of prostaglandin on bone healing process. Twenty-two dogs of different ages were used in the experiment. The left tibia was drilled (5mm in diameter) and 8mm thick at 2mm proximal to the hole. The opposite side of the contralateral bone was used as a control. Prostaglandin administration methods are divided into oral and