胞外基质与细胞的相互作用主要由整合素介导。由整合素介导的机械和生化信号调控胞浆激酶、生长因子受体、离子通道的活性并控制胞内肌动蛋白细胞骨架的组装。众多由整合素介导的信号传导通路最后可归于对细胞周期的调节、决定细胞存活或死亡、增殖或者退出细胞周期和分化。近年的研究发现 ,整合素连接激酶 (inte-grin- linked kinase,IL K)在这些信号传导通路中具有关键作用 The interaction of extracellular matrix with cells is mainly mediated by integrins. Integrin-mediated mechanical and biochemical signals regulate the activity of cytoplasmic kinases, growth factor receptors, ion channels and control the assembly of intracellular actin cytoskeleton. A large number of integrin-mediated signaling pathways can ultimately be attributed to the regulation of the cell cycle that determines cell survival or death, proliferation or withdrawal from the cell cycle and differentiation. In recent years, studies have found that inte-kin-linked kinase (IL-K) plays a key role in these signaling pathways