Ultrasound-assisted synthesis and preliminary bioactivity of novel 2H-1,2,4-thiadiazolo[2,3-a]pyrimi

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Eight novel 5,7-disubstituted-2-{ 5-methyl-3-(4-trifluoromethylphenyl)isoxazol-4-ylcarbonylimino }-2H- 1,2,4-thiadiazolo[2,3-a]pyrimidines were synthesized by multi-step reactions in yields 68-85%.Reactions were carried out either by ultrasound irradiation or conventional method,and found it was faster and more efficient under ultrasonic irradiation.Preliminary herbicidal activities against Echinochloa crus-galli,Digitaria sanguinalis and Chenopodium serotinum were also evaluated by fiat-utensil method,and the results indicated that the target compounds exhibited significant activities,some were even higher than the control herbicide.
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