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本文根据王文余等［１］研究ＩｇＥ及其介导的Ⅰ型变态反应参与流行性出血热（ＥＨＦ）早期发病过程，相继通过多项指标证明Ⅲ型变态反应参与了中晚期发病机制。由于ＥＨＦ病人血清中ＩｇＥ及ＩｇＧ水平不断升高，与相应抗原结合形成ＩｇＥ型和ＩｇＧ型等免疫复合物（ＩＣ），至中晚期达高峰，此时病人血清补体水平明显地下降，单核－巨噬细胞系统，红细胞系统清除免疫复合物功能低下，ＩＣ沉积于血管内膜及肾脏等组织，引起组织免疫损伤。依据这一理论，应用了联合抗过敏疗法加用新鲜血浆，治疗ＥＨＦ中晚期病人，获得显著疗效。
In this paper, according to Wang Wenyu et al [1] to study IgE and its type Ⅰ allergic involvement in the early onset of epidemic hemorrhagic fever (EHF), one after another through a number of indicators that type Ⅲ allergy involved in the pathogenesis of the late. As EHF serum IgE and IgG levels continue to rise, with the corresponding antigen to form IgE and IgG type immune complexes (IC), to the late peak, when the patient serum complement levels decreased significantly, mononuclear - Macrophage system, the erythrocyte system to remove immune complexes dysfunction, IC deposition in the intima and kidney and other tissues, causing tissue immune damage. According to this theory, the combination of anti-allergy plus fresh plasma, the treatment of patients with advanced EHF, to obtain a significant effect.