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目的 :探讨不同临床病理类型的膀胱肿瘤及癌旁组织端粒酶活性表达及临床意义。方法 :以改良TRAP法测定 91例膀胱肿瘤组织标本端粒酶活性表达。结果 :83例膀胱移行细胞癌组织中 78例检测到端粒酶活性 ,阳性率为 94%,其对应的癌旁组织也有 14%的检出率。 8例膀胱乳头状瘤组织中 4例检测到端粒酶活性 ,阳性率为 5 0 %,其对应的癌旁组织检出率为 12 %。端粒酶活性在不同临床病理类型的膀胱肿瘤及癌旁组织中表达差异无显著性意义 (P >0 .0 5 )。结论 :膀胱肿瘤及癌旁组织端粒酶活性的检测对肿瘤的诊断有重要意义。
Objective: To investigate the expression and clinical significance of telomerase activity in different types of bladder cancer and paracancerous tissues. Methods: Telomerase activity was detected in 91 cases of bladder tumor by modified TRAP method. Results: Telomerase activity was detected in 78 cases of bladder transitional cell carcinoma in 83 cases, the positive rate was 94%, and the corresponding paracancerous tissues also had a detection rate of 14%. Telomerase activity was detected in 4 of 8 cases of papilloma of the bladder with a positive rate of 50% and a corresponding rate of paracancerous tissue of 12%. There was no significant difference in telomerase activity between bladder cancer and adjacent normal tissues (P> 0.05). Conclusion: The detection of telomerase activity in bladder tumor and paracancerous tissues is of great significance in the diagnosis of tumors.