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目的:探讨桩蛋白在胃上皮内瘤变的表达及对胃癌预后的影响。方法:应用免疫组织化学技术S-P法,检测20例正常胃黏膜、20例胃黏膜慢性炎、10例萎缩性胃炎、12例胃黏膜上皮内肿瘤、50例胃腺癌中桩蛋白的表达,利用SA S9.0对数据进行分析。结果:桩蛋白细胞骨架蛋白在正常胃黏膜高表达,随着病变加重而表达减弱。在胃癌中显著低于上皮内瘤变(P<0.05),且与胃腺癌的浸润深度、淋巴结转移、TNM分期及生存期等胃癌生物学行为有关。结论:桩蛋白细胞骨架蛋白在胃上皮内瘤变过程中起作用,桩蛋白的失表达对胃癌的预后有重要的临床意义。
Objective: To investigate the expression of paxillin in intraepithelial neoplasia and its effect on the prognosis of gastric cancer. Methods: Immunohistochemical SP method was used to detect the expression of paxillin in 20 normal gastric mucosa, 20 chronic gastric mucosa, 10 atrophic gastritis, 12 gastric intraepithelial neoplasia and 50 gastric adenocarcinoma. S9.0 analyze the data. Results: The pectin cytoskeleton protein was highly expressed in normal gastric mucosa and weakened with the increase of lesions. Which was significantly lower than that of intraepithelial neoplasia (P <0.05) in gastric cancer and was related to the biological behavior of gastric cancer such as the depth of invasion, lymph node metastasis, TNM stage and survival rate. CONCLUSION: Paxillin cytoskeleton protein plays a role in intraepithelial neoplasia. The loss of paxillin protein has an important clinical significance for the prognosis of gastric cancer.