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目的比较首剂不同剂量的肺表面活性物质PS对重度早产儿呼吸窘迫综合征RDS疗效的影响。方法将2005年2月至2012年4月NICU住院治疗的重度RDS患儿46例分为治疗组与对照组,每组23例。首剂大剂量PS组为治疗组,PS用量200mg/kg;首剂小剂量PS组为对照组,PS用量100mg/kg。比较两组患儿的用药总剂量,使用PS前及6h后的血气分析、PaO2/FiO2及机械通气时间、住院监护时间。结果两组患儿在PS用药总剂量方面差异无统计学意义(P>0.05)。治疗组患儿在机械通气时间,氧疗时间、住院监护时间等均显著低于对照组,差异有统计学意义(P均<0.05)。PS治疗6h后两组患儿的PaO2、PaO2/FiO2均较治疗前显著升高(P均<0.05)。但升高的程度两组间差异无统计学意义(P>0.05)。结论 PS首剂治疗量达200mg/kg时治疗重度RDS的效果优于首剂治疗量100mg/kg。
Objective To compare the effects of the first dose of pulmonary surfactant PS on the efficacy of RDS in severe preterm infants with respiratory distress syndrome. Methods From February 2005 to April 2012, 46 children with severe RDS admitted to NICU hospital were divided into treatment group and control group, with 23 cases in each group. The first dose of high-dose PS group for the treatment group, PS dose of 200mg / kg; the first dose of low-dose PS group as the control group, PS dose of 100mg / kg. The total dose of the two groups of children was compared, using blood gas analysis before and after 6h, PaO2 / FiO2 and mechanical ventilation time, hospitalization time. Results There was no significant difference in the total dose of PS between the two groups (P> 0.05). The treatment group of children in the mechanical ventilation time, oxygen therapy time, hospitalization time were significantly lower than the control group, the difference was statistically significant (P all <0.05). PaO2 and PaO2 / FiO2 in both groups were significantly higher than those before treatment after PS treatment for 6h (all P <0.05). However, there was no significant difference between the two groups (P> 0.05). Conclusion The first dose of PS treatment 200mg / kg when the treatment of severe RDS better than the first dose of 100mg / kg.