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全国13省市共23个单位,对不锈钢金属单环、V Cu200及T Cu220c三种宫内节育器(IUD)进行随机临床多中心比较性研究。自1987年7月1日至1984年3月31日共接受对象6236例。五年末随访率为96.0%。60个月时每百妇女累积续用率以金单为最低,55.8%,V Cu及T Cu各为68.8%及72.4%。V Cu和T Cu的妊娠率分别为7.32%和7.24%,显著地低于金单的20.2%。60个月时金单、V Cu和T Cu的脱落率分别为19.0%、9.7%和5.6%,三者间呈显著性差异。因出血和/或疼痛取出率以金单为最低,二种带铜宫内节育器间无差别。三种IUD使用情况城市与农村间比较,城市的累积续用率均高于农村;妊娠、脱落和个人原因停用农村均高于城市。用Cox比例危险模型和似然比检验,发现金单的失败危险与以下因素有关:年龄、过去IUD使用史、劳动姿态、孕次和宫腔深度;前四个因素对VCu失败危险有影响;TCu失败危险除与前三个因有关外,哺乳期放器对其失败危险亦有影响。年龄和孕次均影响三种IUD的妊娠危险;过去IUD使用史分别作用于金单和VCu;宫腔深度分别影响金单和TCu的妊娠。T Cu的脱落仅受哺乳期放器影响;年龄、孕次、过去IUD使用史影响着VCu的脱落;金单脱落除上述三因素外,还受宫腔深度的影响,且前三个因素均呈极显著性差异。
A total of 23 units in 13 provinces and cities nationwide, the stainless steel metal single ring, V Cu200 and T Cu220c three intrauterine devices (IUD) were randomized clinical multicenter comparative study. From July 1, 1987 to March 31, 1984 a total of 6236 cases were accepted. The five-year follow-up rate was 96.0%. At 60 months, the accumulative reutilization rate per 100 women was the lowest with 55.8% for gold and 68.8% for V Cu and 72.4% for T Cu. Pregnancy rates for V Cu and T Cu were 7.32% and 7.24%, respectively, significantly lower than those of 20.2%. At 60 months, the shedding rates of gold single, V Cu and T Cu were 19.0%, 9.7% and 5.6% respectively, with significant differences among them. Due to bleeding and / or pain removal rate to the lowest gold, two copper with IUD no difference between. Three kinds of IUD usage Comparison of urban and rural areas, the cumulative urban renewal rate are higher than in rural areas; pregnancy, shedding and personal reasons are higher than the urban disabled rural areas. Using Cox proportional hazards model and likelihood ratio test, it was found that the failure risk of gold list was related to age, history of past IUD use, labor attitude, gestational age and uterine cavity depth. The first four factors had an impact on the risk of VCu failure. Failure of TCu In addition to the first three causes, the lactation device also has an effect on its risk of failure. Age and gestational age all affect the pregnancy risk of three kinds of IUD; the history of IUD usage in the past were respectively applied to gold single and VCu; uterine cavity depth affected the pregnancy of gold single and TCu respectively. T Cu shedding is only affected by the lactation of the release device; age, gestational age, the history of the past IUD affect VCu shedding; gold single shedding in addition to the above three factors, but also by the depth of the uterine cavity, and the first three factors Was a very significant difference.