作者先前证实了抗凝血酶Ⅲ降低鼠内毒素激活的白细胞引起的内皮细胞损伤。这是通过内皮释放前列腺素Ⅰ_2(一种有效的白细胞激活抑制物)的增加而实现的。在内毒素处理的鼠中,作者通过比较不同剂量的抗凝血酶-Ⅲ对肺血管损伤的影响,评价了阻止此类内皮细胞损伤所需的抗凝血酶-Ⅲ的剂量。静脉内给予内毒素(5mg/Kg),正如肺血管通透性增加显示的那样,伴随着肺血管损伤,产生一个短暂的白细胞聚积及血凝异 The authors previously demonstrated that antithrombin III reduces endothelial cell injury induced by murine endotoxin-activated leukocytes. This is achieved by the increase of endothelium releasing prostaglandin I2 (a potent inhibitor of leukocyte activation). In endotoxin-treated mice, the authors evaluated the dose of antithrombin-III required to prevent damage to such endothelial cells by comparing the effects of different doses of antithrombin-III on pulmonary vascular injury. Endotoxin (5 mg / kg) is administered intravenously, as shown by increased pulmonary vascular permeability, accompanied by pulmonary vascular damage resulting in a transient leukocyte accumulation and hemagglutination