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目的:探讨甲氨蝶呤联合米非司酮治疗异位妊娠的临床疗效。方法:选取我院在2011年9月~2013年9月收治的88例异位妊娠患者作为研究对象,随机将其分为2组(治疗组、对照组),每组44例,对照组患者单用甲氨蝶呤,治疗组患者在对照组基础上,加用米非司酮,对比两组患者的治疗效果。结果:治疗组治愈率88.6%,对照组63.6%,治疗组的治愈率显著高于对照组,P<0.05,差异具有统计学意义;治疗组在2周内临床症状消失、3周内妊娠包块缩小方面,发生率均显著高于对照组,P<0.05;治疗组患者的β-HCG恢复正常时间明显比对照组更短,P<0.05。结论:与单用甲氨蝶呤相比,甲氨蝶呤联合米非司酮治疗异位妊娠的疗效更显著,且不会增加不良反应,具有重要的推广应用价值。
Objective: To investigate the clinical efficacy of methotrexate combined with mifepristone in the treatment of ectopic pregnancy. Methods: A total of 88 patients with ectopic pregnancy admitted to our hospital from September 2011 to September 2013 were randomly divided into two groups (treatment group and control group), 44 patients in each group and control group Methotrexate alone, the treatment group patients in the control group, based on the addition of mifepristone, compared two groups of patients with treatment. Results: The cure rate was 88.6% in the treatment group and 63.6% in the control group. The cure rate of the treatment group was significantly higher than that of the control group (P <0.05), and the difference was statistically significant. The clinical symptoms of the treatment group disappeared within 2 weeks, Block reduction, the incidence was significantly higher than the control group, P <0.05; the treatment group patients with β-HCG recovery significantly shorter than the control group, P <0.05. Conclusion: Compared with methotrexate alone, methotrexate combined with mifepristone treatment of ectopic pregnancy more significant effect, and does not increase adverse reactions, has an important application value.